Cis-diamminedichloroplatinum delivery system using poly (lactic acid).

Poly (Lactic Acid)Nanofibres as Drug Delivery Systems: Opportunities and Challenges

Numerous Scientists have discovered the procedure of nanotechnology, explicitlynanofibers, asdrug delivery systems for transdermal uses. Nanofibers canbe used to deliver drugs and are capable of controlled release for a continued periodof time. Poly (Lactic Acid) (PLA) is the lastly interesting employed synthetic polymer in biomedical application owing to its well categorized biodegradable prop...

Increasing the Efficiency of Parkinson's Disease Treatment Using a poly(lactic-co-glycolic acid) (PLGA) Based L-DOPA Delivery System

To compare the efficacy of L-DOPA administered intranasally in the form of nanoparticles (nano-DOPA) and in standard drug forms using a rat Parkinson's Disease (PD) model. L-DOPA-containing nanoparticles (250±50 nm) were synthesized using the double emulsion method. The efficacy of nano-DOPA therapy was studied in Wistar rats with 6-OHDA-induced PD. Drugs were administered daily, 0.35 mg/kg (by...

Functional Properties of Biodegradable Nanocomposites from Poly Lactic Acid (PLA)

Nanocomposite composed of organoclay(Cloisite 20A-C20A) and Poly lactic acid (PLA) was prepared by solvent casting method. Physical, mechanical, thermal, barrier and microstructure properties of the composite were studied. X-Ray diffraction (XRD) patterns and scannin...

Renal complications of cis-diamminedichloroplatinum.

The use of cis-diamminedichloroplatinum II (DDP), an active agent against special cancer types, is limited by its nephrotoxicity. It damages the proximal tubular epithelium and may cause specific tubular dysfunctions, such as elevation of enzymes and 2 beta microglobulin in the urine or, under special conditions, low calcium and/or magnesium serum concentrations. Cis-diamminedichloroplatinum II...

Poly(lactic acid) (PLA) Nanofibers for Bone Tissue Engineering